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With an increased prevalence of chronic, inflammatory and age-related disease, there is an unmet need to provide novel and effective therapies that cure diseases or provide long-term positive effects. One potential approach to this challenge is to generate new cures based on cell-therapy. Cell-therapies, or “cytotherapies”, rely on laboratory-expanded cells to promote healing, regulate the immune system and/or kill malignant cells. In some approaches, cells from a patient are grown in tissue culture under conditions that stimulate therapeutic capacity prior to re-administration (autologous cell therapy), in other cases, a large batch of universally compatible cells are produced as an “off-the-shelf” product (allogeneic cell therapy). This proposal will likely benefit both cytotherapeutic paradigms, but we have focused on challenges with allogeneic cell manufacture. The growth of cell-therapy is clearly demonstrated by a continued increase in clinical trials over the last 15 years (by 450%, clinicaltrials.gov), the recent adoption of mesenchymal stem cell (MSC) therapy for treatment of refractory graft-versus-host disease in Europe, the FDA approval of chimeric antigen receptor T-cell (CAR-T) therapy for treatment of some cancers in 2017 and a projected increase in the cytotherapeutic cell banking industry by over 300% between 2012 and 2022 (grandviewresearch.com). Furthermore, world’s largest manufacturing facility dedicated to cell and gene therapy will soon resume operations in Houston, TX. Nevertheless, there are technical issues that will impede future large scale manufacture of cytotherapeutic products as needs increase.

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慢性、炎症および加齢に伴う疾患の増加率、小説と病気を治すか、または長期的なプラスの効果を提供する効果的な治療法を提供するために満たされていない必要があります。この挑戦に 1 つの潜在的なアプローチは、細胞療法に基づく新しい治療法を生成することです。研究所-e に依存して細胞治療、または"cytotherapies"、

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There have not been met in order to provide an effective cure for increasing rates of disease associated with chronic inflammation and aging and novel disease to cure or to provide a long term positive effect. A new therapeutic method based on cell therapy is one potential approach to this challenge form

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そこが満たされていない慢性炎症および加齢と疾患の新規病を治すにまたは長期的に肯定的な効果を提供するために率を高めるための効果的な治療を提供するために。細胞療法に基づく新しい治療法はこの挑戦のフォームに 1 つの潜在的なアプローチ

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Cure new diseases have not met there is chronic inflammation and aging and diseases or to provide effective treatment to increase the rate to provide a positive effect in the long run. New therapeutic approaches based on cell therapy in the form of this challenge one potential approach

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新しい病気の治療法を満たしていない慢性炎症および加齢と疾病があるか肯定的な効果を長期的に提供するために率を高めるための効果的な治療法を提供します。新しい治療上のアプローチに基づいてこの挑戦状の細胞療法 1 つの潜在的なアプローチ

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Provides an effective treatment to increase the rate to provide long term positive effects that chronic inflammation does not meet new disease treatments, aging and disease. New therapeutic approaches based on potential approaches for cell therapy one of the challenge

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新しい病気の治療、老化や病気慢性炎症長期的肯定的な効果を提供するために率を高めるための効果的な治療法を満たしていないを提供します。細胞療法の挑戦の 1 つの潜在的なアプローチに基づく新しい治療上のアプローチ

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New treatment of disease, aging and disease chronic inflammatory term does not meet an effective treatment to increase the rate to provide a positive effect provides. New therapeutic approaches based on a potential approach for cell therapy challenge

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新しい治療病、老化や病気の慢性の炎症性の言葉が肯定的な効果を提供を提供するために率を高めるための効果的な治療法を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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An effective treatment to increase the rate for new cure disease, aging and chronic diseases inflammatory words provides a positive effect does not meet. New therapeutic approaches based on a potential approach for cell therapy challenge

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新しい治療疾患の率を高めるための効果的な治療法加齢や慢性疾患炎症性の言葉は、肯定的な効果を満たしていないを提供します。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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To increase the rate of new treatment for an effective treatment method for aging and chronic diseases inflammatory words does not meet the positive effects on the offer. New therapeutic approaches based on a potential approach for cell therapy challenge

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効果的な治療の新しい治療法の率を高めるため高齢化、慢性疾患炎症性言葉のメソッドは提供の肯定的な効果を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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To increase the rate of treatment effective new treatments for aging and chronic diseases inflammatory Word method does not meet the positive effect of the provision. New therapeutic approaches based on a potential approach for cell therapy challenge

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高齢化や慢性疾患の治療の効果的な新しい治療法の率を高めるため炎症性単語メソッドが規定の正の効果を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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To raise the rate of an effective new treatment for the treatment of aging and chronic diseases inflammatory Word method does not meet the positive effect of the provision. New therapeutic approaches based on a potential approach for cell therapy challenge

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高齢化や慢性疾患の治療に効果的な新しい治療の率を高めるため炎症性単語メソッドが規定の正の効果を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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To increase the rate of a new therapy effective in the treatment of aging and chronic diseases inflammatory Word method does not meet the positive effect of the provision. New therapeutic approaches based on a potential approach for cell therapy challenge

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新しい治療の率を高めるため高齢化や慢性疾患の治療に効果的な炎症性単語方式を満たさない規定の肯定的な効果。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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Increase the rate of new treatment method effective in the treatment of aging and chronic diseases inflammatory words that do not meet the provisions of positive effects. New therapeutic approaches based on a potential approach for cell therapy challenge

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肯定的な効果の規定を満たしていない高齢化および慢性の疾患炎症性言葉の治療に効果的な新しい治療法の率を高めます。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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Increase the rate of treatment do not meet the provisions of the positive effects of aging and chronic diseases inflammatory words of effective new treatments. New therapeutic approaches based on a potential approach for cell therapy challenge

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治療率を高める効果的な新しい治療法の高齢化、慢性疾患の炎症性言葉の肯定的な効果の規定を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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Does not meet the provisions of the positive effects of the inflammatory words of effective new treatments to increase the cure rate of aging and chronic disease. New therapeutic approaches based on a potential approach for cell therapy challenge

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高齢化や慢性疾患の治癒率を高めるための効果的な新しい治療法の炎症性の言葉の肯定的な効果の規定を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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Does not meet the provisions of the positive effects of an effective new treatments to increase the healing rate of aging and chronic diseases inflammatory words. New therapeutic approaches based on a potential approach for cell therapy challenge

INTO JAPANESE

高齢化、慢性疾患炎症性言葉の治癒率を高めるための効果的な新しい治療法の効果の規定を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

BACK INTO ENGLISH

Does not meet the provisions of effective new treatments to increase the healing rate of aging and chronic diseases inflammatory words. New therapeutic approaches based on a potential approach for cell therapy challenge

INTO JAPANESE

高齢化、慢性疾患炎症性言葉の治癒率を高めるための効果的な新しい治療法の規定を満たしていません。細胞療法の挑戦のための潜在的なアプローチに基づく新しい治療上のアプローチ

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Does not meet the provisions of effective new treatments to increase the healing rate of aging and chronic diseases inflammatory words. New therapeutic approaches based on a potential approach for cell therapy challenge